IMR Press / EJGO / Volume 19 / Issue 1 / pii/1998109

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Malignancy arising in extraovarian endometroisis during estrogen stimulation

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1 University of Graz, Department of Obstetrics and Gynecology, Graz, Austria
Eur. J. Gynaecol. Oncol. 1998, 19(1), 39–41;
Published: 10 February 1998

Objective: Endometriosis can undergo estrogen-dependent changes similar to endometrium and may carry a risk of developing hyperplasia and carcinoma during unopposed estrogen stimulation. Material-method: We reviewed the existing literature to analyze the potential of a malignancy arising from extraovarian endometriosis by estrogen stimulation. Results: To our knowledge, there are 20 published cases so far, with a malign transformed endometriosis during estrogen stimulation at an extraovarian site. The most common site of malignancy arising from endometriosis was the vagina (n = 5). The most common histological finding was adenocarcinoma (n = 13). The incidence of malignant transformation in extraovarian endometrio­sis during unopposed estrogen replacement can not be estimated based upon these case reports. Conclusion: Unopposed estrogen stimulation may lead to premalignant or malignant transformation in the residual foci of endo­metriosis. Therefore, the addition of progestins to estrogen replacement therapy should be considered in women who have under­gone hysterectomy with oophorectomy because of endometriosis, especially if they are known to have residual endometriosis.

Estrogen replacement
Hormone replacement
Malignancy arising
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