European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Steroid hormones play a major role in the development and, growth of endometrial and breast cancer. Besides regulating the proliferation of cells susceptible to carcinogens or initiated by carcinogens, steroid hormones can modulate the growth factor system either directly or indirectly in normal and neoplastic endometrial and breast tissue. The present article analyzes the experimental data on the interactions between steroid hormones and growth factor system in these tissues. Epidemiologic studies on the risk of endometrial and breast cancer in oral contraceptive or hormone replacement therapy users are also reviewed.