IMR Press / EJGO / Volume 18 / Issue 2 / pii/1997135

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

A case of malignant melanoma of the vagina during pregnancy: immunological problems

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1 Department of Obstetric and Gynecology, Second University of Naples, Italy
Eur. J. Gynaecol. Oncol. 1997, 18(2), 136–138;
Published: 10 April 1997

Background: A clinical case of malignant melanoma of the vagina diagnosed during late pregnancy is described. Prompt histolo­gical examination showed a malignant melanoma at an early stage. The treatment of choice for malignant melanoma is surgical exicision. At present we are trying to associate immunological and chemotherapeutic treatments with surgical ones. Case: A 27-year-old primipara was diagnosed with malignant melanoma at 38 weeks'gestation. The patient underwent a cesarean section. Careful evaluation of the immunological characteristics of the patient induced us to treat the melanoma with human leukocyte alpha interferon. The result was an increase in T4 cells with respect to T8 cells, with an enhancement in the ratio of CD4 to CDS. Conclusion: The results suggest the immune system plays a major role in the modification and regulation of neoplasias of the genital tract.

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