IMR Press / EJGO / Volume 18 / Issue 1 / pii/1997122

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Diagnostic and therapeutic technique of cervical conization with “cold knife” using fibrin glue. Preliminary outcomes

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1 Department of Obstetrics and Gynaecology, S. Filippo Neri Hospital, Rome, Italy
Eur. J. Gynaecol. Oncol. 1997, 18(1), 84–86;
Published: 10 February 1997

In recent years many Authors have proposed several techniques and surgical tools to perform conical or cylindrical excisions of the portio and cervical canal. For instance, we can perform conization using a traditional“cold knife” (scalpel), CO2 laser with focal bundle, radiothermic or fine needle electroconization (Loop Electrosurgical Excision Procedure - LEEP -; Large Loop Excision of Transition Zone - LLETZ -). Our goal has been to change traditional conization of the cervix with "cold knife" using Hegar dilatators to delineate the cone we have to remove and prevent lesions in the cervical canal; furthermore, using fibrin glue (Tissucol-R) to do a considerable haemo­stasis. The performance takes about five minutes under local anaesthesia and it has been possible to study the patients with a 24- month follow up. The results the Authors obtained have been low blood loss, diagnostic and histological accuracy, better colposcopic follow-up, any angle-shots or abnormality of the cervical canal and any physical-chemical modifications of the ovulatory cervical mucus. The advantages of traditional conization we modified are still valid; however, others procedures have a clinical and therapeutical signi­ficance but concerning histological and diagnostic investigations they could give a negative result.

CIN (Cervical Intraepithelial Neoplasia)
LEEP (Loop Electrosurgical Excision Procedure)
Fibrin tissue adhevise
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