IMR Press / CEOG / Special Issues / 1615524725515

Uterus Transplantation: current evidences, open questions and future directions

Submission deadline: 30 September 2021
Special Issue Editors
Paolo Scollo, MD
Division of Gynecology and Obstetrics, Maternal and Child Department, Cannizzaro Hospital-Italian Society of Gynecology and Obstetrics (SIGO), Catania 95126, Italy
Interests: Obstetrics; Gynecology
Mats Brännström, MD
Department of Obstetrics and Gynecology, University of Gothenburg, Göteborg, Sweden
Interests: Ovulation mechanisms; Effects of prophylactic oophorectomy; Uterus transplantation; Bioengineered uterus and ovary; Ovarian cryopreservation
Giuliano Testa, MD
Baylor Scott & White Transplant Services, Dallas, United States
Interests: Abdominal transplant; Uterine transplant
Special Issue Information

Dear Colleagues,

Uterus transplantation (UTx) is now a real opportunity for women affected by absolute uterine factor infertility (UFI) to get pregnancy. UFI, either congenital or acquired, affects 1 in 500 fertile-aged women. The most frequent congenital reason for UFI is MRKH syndrome. 

UTx represents a special event in the field of transplantation: it’s a temporary transplant, non-lifesaving and involving several parts. There are two valid options for donation: living or deceased. In fact, it has been highlighted that both options are possible to deliver a child. Scientific researches about Utx had involved many continents in the world (America, Europe and Asia), to date, several groups have performed more than 70 UTx procedures in total, resulting in the delivery of more than 30 newborns according to the available literature and media. The first baby after UTx from living donor was born in Sweden by Brännström et al. in September 2014. First live birth after Utx in the United States was published in 2018 by Testa et al. After the first live birth after Utx from deceased donor in Brazil in 2017, research about Utx from brain dead donor was performed in many countries, including USA, Chech Republic and Italy. 

However, UTx is still in the experimental stage and there are many medical, surgical, psychological and ethical issues to be resolved. 

It’s necessary to investigate about comparison between live and deceased donor trial in order to understand if a better option exists or both options are equally valid. Issues about surgical retrieval (open, laparoscopy and robotic), graft explantation with vascular connessions and alternative drainage outflow (ovaric vein) are highly debated. There are also many sentences to be answered about psychological assessment, considered data of literature about the importance of psycological support in the patients affected from UFI and particulary MRKH syndrome. 

The global emergency from COVID-19 pandemic determined almost 2 million of deaths worldwide, damaged in many cases the ordinary medical assistence in the last year, overshadowing not essential services and making difficult for people to access in the hospitals for Utx.

The aim of this Special Issue is to resume the current state-of-art about UTx, discussing debated issues in UTx, and to develop new ideas for the future.

Prof. Paolo Scollo, Prof. Mats Brännström and Dr. Giuliano Testa

Guest Editors

Keywords
Uterus transplantation
Deceased donor
Live donor
MRKH syndrome
Surgery
Psychological
Manuscript Submission Information

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Published Paper (3 Papers)
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Open Access Review
Uterus bioengineering as a future alternative to uterus transplantation
Arvind Manikantan Padma, Mats Brännström, Mats Hellström
Clin. Exp. Obstet. Gynecol. 2022, 49(3), 72; https://doi.org/10.31083/j.ceog4903072
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Open Access Original Research
Diminished ovarian reserve and ectopic ovaries in patients with Mayer-Rokitansky-Küster-Hauser syndrome candidates for Uterus Transplantation: our experience
Basilio Pecorino, Giuseppe Scibilia, Placido Borzì, Maria Elena Vento, ... Paolo Scollo
Clin. Exp. Obstet. Gynecol. 2021, 48(4), 907–912; https://doi.org/10.31083/j.ceog4804143
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