IMR Press / CEOG / Volume 6 / Issue 4 / pii/1634267390296-1817171598

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
On the abortifacient mechanism of 15(S)15-methyl-prostaglandin F in early pregnancy
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1 Department of Obstetrics and Gynecology, University of Cagliari
Clin. Exp. Obstet. Gynecol. 1979, 6(4), 292–296;
Published: 10 December 1979

To induced abortion serial intramuscular injections of 15 (S)15-Methyl-Prostaglandin F were given to twelve volunteering women, in their eighth to eleventh week of gestation. The abortifacient effectiveness and changes in foetoplacental function during the treatment were evaluated. The uterine activity began from 15 to 50 minutes and vaginal bleeding started from 1.9 to 7. 5 hours after the start of the procedure. All patients aborted within 24 hours. The oestradiol, progesterone, human chorionic somatomammotropin and beta subunit of human chorionic gonadotropin plasma values significantly dropped three hours after the first injection. the alpha-fetoprotein pasma levels significantly rose after six hours. These results suggest that 15(S)15-Methyl-Prostaglandin F oxytocic effect plays an important role to induce first trimester abortion.
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