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On the abortifacient mechanism of 15(S)15-methyl-prostaglandin F2α in early pregnancy
1 Department of Obstetrics and Gynecology, University of Cagliari
Clin. Exp. Obstet. Gynecol. 1979, 6(4), 292–296;
Published: 10 December 1979
To induced abortion serial intramuscular injections of 15 (S)15-Methyl-Prostaglandin F2α were given to twelve volunteering women, in their eighth to eleventh week of gestation. The abortifacient effectiveness and changes in foetoplacental function during the treatment were evaluated. The uterine activity began from 15 to 50 minutes and vaginal bleeding started from 1.9 to 7. 5 hours after the start of the procedure. All patients aborted within 24 hours. The oestradiol, progesterone, human chorionic somatomammotropin and beta subunit of human chorionic gonadotropin plasma values significantly dropped three hours after the first injection. the alpha-fetoprotein pasma levels significantly rose after six hours. These results suggest that 15(S)15-Methyl-Prostaglandin F2α oxytocic effect plays an important role to induce first trimester abortion.