IMR Press / CEOG / Volume 5 / Issue 3-4 / pii/1634267654401-874392774

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Leucocytic iso-immunization in pregnancy
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1 Obstetric Gynaecological Clinic, University of Padua
2 1st Medical Clinic, University of Padua
Clin. Exp. Obstet. Gynecol. 1978, 5(3-4), 138–145;
Published: 10 September 1978
Abstract

The results of a study on leucocytic iso-immu-nization in pregnancy and on the antibody characteristics of the sera produced are reported. The investigation was carried out on 774 puerperae, making use of the cytotoxicity reaction The results may be summed up as follows: a) pregnancy constitutes an important cause of leucocytic iso-immunization; b) leucocytic iso immunization may occur either in primiparae or multiparae, but the relation between the two isoimmunization percentages was not statistically significant; c) the lymphocytotoxis sera may show direct antibody specificity towards either the known antigens as listed in the Major Ristocompatibility System, or else antigens not yet defined; d) the spectrum of antibody spedficity varies in relation to the temperature at which the reaction occurs but does not seem to be influenced significantly by the number of pregnancies; e) the antibody specificities obtained, do not always correspond to those expected on the basis of SD1 and SD2 phenotypes of women and their respective husbands.
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