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Diagnosis and treatment of patients who have become sterile due to prolactin-secreting pituitary aden oma
1 II Obstetric and Gynaecological Clinic, University of Rome
2 I Obstetric and Gynaecological Clinic, University of Rome
3 Department of Obstetrics and Gynecology, Westfalische Wilhelms Universitat, Munster - Germany
Clin. Exp. Obstet. Gynecol. 1978, 5(3-4), 93–103;
Published: 10 September 1978
The present study reports the endocrinological and radiological features of 10 hyperpro-lactinaemic patients with macro (4 patients) and microadenoma (6 patients) of the pituitary. A more affected hormonal situation seems to be present in patients where more pronoun-ced radiographic changes are found. In the light of this evidence it appears that polytomography of the sella is mandatory wherever a microadenoma of the pituitary has to be ruled out. CB-154 treatment appears to be mostly effective in the tratment of hyper-prolactinaemic patients, resulting within few months in resumption of menses and ovulation. The risk of pregnancy and the possible thera-peutic approaches to the problem are discussed.