IMR Press / CEOG / Volume 49 / Issue 8 / DOI: 10.31083/j.ceog4908174
Open Access Original Research
Development of a Nomogram for Preoperative Prediction of Emergency Peripartum Hysterectomy with Postpartum Haemorrhage: A Chinese-Population-Based Study
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1 Department of Obstetrics, Ningbo Women and Children’s Hospital, 315012 Ningbo, Zhejiang, China
*Correspondence: zhoujunjunpp@163.com (Junjun Zhou)
Academic Editor: Michael H. Dahan
Clin. Exp. Obstet. Gynecol. 2022, 49(8), 174; https://doi.org/10.31083/j.ceog4908174
Submitted: 2 March 2022 | Revised: 24 April 2022 | Accepted: 28 April 2022 | Published: 26 July 2022
(This article belongs to the Section Gynecologic surgery)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Objective: To develop and validate a model to predict the incidence of emergency peripartum hysterectomy (EPH) due to postpartum haemorrhage (PPH) from the time of delivery to 6 weeks postpartumin the duration of caesarean section (C-section). Methods: There were 627 patients with PPH including in this retrospective study from 2015 to 2019. Among these patients, 439 patients were divided into the model development group and 188 patients were divided into the validation group. The validation group was constructed for external validation in the usage of bootstrap resampling. The least absolute shrinkage and selection operator (LASSO) regression model was used to reduce the data dimension, and select features and independent risk factors. Results: In total, the incidence rate of PPH and EPH was 7.53% (2145/284,912) and 2.73‰ (78/28,491) among the 28,491 patients with C-section, respectively. The results of LASSO regression indicated that prothrombin time decrease at 60 minutes after C-section (odds ratio (OR) = 1.823, 95% confidence interval (CI): 1.171–2.839) and placenta previa (OR = 5.374, 95% CI: 2.751–10.393) were positively associated with EPH in this study, while gestational age at termination (OR = 0.959, 95% CI: 0.930–0.989) and albumin decrease at 60 minutes after C-section (OR = 0.907, 95% CI: 0.843–0.976) had negative association with EPH. Besides, we found that the C-index was 0.896 for the primary cohort and 0.899 for the validation cohort in the prediction nomogram, respectively. Conclusions: In this retrospective study, an EPH nomogram within several risk factors, which was constructed by LASSO regression, can be contributed to effectively predict the risk of EPH in patients with PPH during C-section. In addition, a significant association is observed between abnormal placenta and peripartum hysterectomy.

Keywords
peripartum hysterectomy
prediction
postpartum haemorrhage
caesarean deliveries
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