IMR Press / CEOG / Volume 49 / Issue 7 / DOI: 10.31083/j.ceog4907146
Open Access Systematic Review
Does Continuous Glucose Monitoring Help in Pregnant Women?
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1 Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807 Kaohsiung, Taiwan
2 School of Post Baccalaureate Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan
3 Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan
*Correspondence: (Te-Fu Chan)
These authors contributed equally.
Academic Editors: Luca Roncati and Shigeki Matsubara
Clin. Exp. Obstet. Gynecol. 2022, 49(7), 146;
Submitted: 2 April 2022 | Revised: 29 April 2022 | Accepted: 1 May 2022 | Published: 30 June 2022
(This article belongs to the Special Issue Metabolic Syndrome in High-Risk Pregnancy)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Diabetes is present in approximately 7% of all pregnancies. Maternal glucose control is a crucial issue. Evidence had demonstrated that optimal glycemic control during the first trimester could reduce congenital anomalies and perinatal mortality; likewise, during second and third trimester, it is also associated with reduced rates of pre-eclampsia, preterm delivery, large for gestational age and neonatal intensive care unit admissions. The aim of this review is to evaluate the current evidences about the glycemic control effects of continuous glucose monitoring (CGM) in pregnant women. Methods: We searched the PubMed database from January 1, 2011 to July 20, 2021, for English-language studies related to CGM uses in pregnancy. We mainly focused on randomized clinical trials (RCTs) and secondary analyses of RCT data. Results: After filtering, 14 researches were adopted by this study. We analyzed the results and sorted them into 4 main aspects, including difference between the outcomes of CGM users verses self-monitored blood glucose (SMBG) users, comparison of different modes of CGM, satisfaction of CGM, and using CGM to monitor glycemic levels in pregnant women under antenatal corticosteroids or ritodrine treatment. Conclusions: There is adequate evidence showing that CGM is effective at monitoring glycemic levels, improving maternal glycemia control as well as aiding with the insulin treatment, with more precise insulin dose.

high risk pregnancy
diabetes mellitus
gestational diabetes mellitus
continuous glucose monitoring
self-monitored blood glucose
Fig. 1.
KMUH107-7R37/Kaohsiung Medical University Research foundation
KMUH 108-8R43/Kaohsiung Medical University Research foundation
KMUH-S10907/Kaohsiung Medical University Research foundation
KMUH-S11007/Kaohsiung Medical University Research foundation
KMUH11010/Kaohsiung Medical University Research foundation
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