Academic Editors: David H. Barad and Michael H. Dahan
Objective: Uterus transplantation (UTx) has evolved as the first true
infertility treatment for absolute uterine factor infertility (AUFI), caused by a
lack (congenital or surgical) of the uterus or presence of a non-functional
uterus. Ever since the proof-of-concept of UTx as an infertility treatment, by
the first live birth in 2014, the field has evolved with a number of ongoing
clinical trials in several countries. Results are now gradually building up to
estimate the efficacy of the procedure in terms of outcome of assisted
reproduction, including live births. An update of these results will be presented
along with our own experience. Mechanism: PubMed search for research
articles with human UTx procedures. Findings in Brief: We could identify
62 UTx cases with data from research articles in peer-reviewed journals. Out of
these, 51 were live donor procedures and 11 were deceased donor UTx. Surgical
success was 78% in live donor UTx and 64% in deceased donor UTx. Limited data
indicate a pregnancy and live birth rate per embryo transfer (ET), somewhat lower
that in the general IVF population. The 24 published live births were premature
(