Background: In young women, combined hormonal contraceptives can
ameliorate menstrual pain and reduce menstrual loss, but their efficacy in
adenomyosis has not been proven. The aim of this study was to investigate whether
ultrasound features of adenomyosis are modified by a combined hormonal
contraceptive containing dienogest. Methods: Fifty-eight out of 173
premenopausal women consecutively attending our university hospital outpatient
service for contraception were enrolled in this observational study. Women with
menstrual pain or heavy menstrual bleeding underwent ultrasonography. An expert
sonographer diagnosed or excluded adenomyosis and fibroids via morphological
uterus sonographic assessment (MUSA). The intensity of menstrual pain was
quantified by each patient on a visual analogue scale (VAS). A total of 38 women
with and 20 without ultrasound features of adenomyosis received dienogest-based
hormonal contraceptive and had a follow-up ultrasound after 6 months of
treatment. Results: During treatment, uterine volume decreased
by –13.1
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Original Research
Dienogest-based hormonal contraception induced changes in the ultrasound presentation of the uterus and menstrual pain
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1
Department of Neuroscience, Obstetrics and Gynecology Unit, Rehabilitation, Ophthalmology, Genetics and Maternal and Paediatric Sciences, University of Genova, 16136 Genova, Italy
2
Department of Medical Area, Obstetrics and Gynecology Unit, Ospedale S. Maria della Misericordia, Azienda Friuli Centrale, 33100 Udine, Italy
3
Department of Obstetrics Gynecology and Pediatrics, Obstetrics and Gynecology Unit, Azienda Sanitaria Universitaria Policlinico di Modena, 41121 Modena, Italy
*Correspondence: angelo.cagnacci@unige.it (Angelo Cagnacci)
Clin. Exp. Obstet. Gynecol. 2021, 48(5), 1186–1192;
https://doi.org/10.31083/j.ceog4805189
Submitted: 10 February 2021 | Revised: 12 May 2021 | Accepted: 28 May 2021 | Published: 15 October 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Dienogest
Hormonal contraception
Ultrasonography
Adenomyosis
Chronic pelvic pain
Heavy menstrual bleeding
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