Background: Congenital heart defects are the most common of
birth defect, which leads to neonatal death after birth. Early diagnosis during
prenatal period would be a benefit for precaution and treatment. Antegrade Late
Diastolic Arterial blood Flow (ALDAF) was reported to measure fetal
atrioventricular (AV) time intervals (FAVTI) at an early gestational ages (GA) of
6 weeks. There has been no previous studies reporting reference value of fetal
atrioventricular time intervals (FAVTI) derive from ALDAF technique.
Methods: Using fetal echocardiogram, this cross-sectional study was
performed on 528 healthy fetuses between 14 and 40 weeks. Pulsed wave
Doppler-derived FAVTI (milliseconds) were measured from ALDAF-AO and ALDAF-PA and
left ventricle (LV) In/Out. Correlations between these three Doppler measurement
techniques were examined with the Bland-Altman analysis and Pearson correlation
coefficient. GA was used as specific reference value and its correlation with
FAVTI was examined with linear regression. Results: We establish
reference values of fetal atrioventricular (AV) time intervals (FAVTI) from
antegrade late diastolic arterial blood flow (ALDAF) aorta (AO) and pulmonary
artery (PA) from 14 to 40 weeks of gestation (GA). A positive correlation between
FAVTI and GA was identified when using each of the three measurements
(ALDAF-AO/ALDAF-PA and LV In/Out) (R2 = 0.177–0.272; P
Announcements
Open Access
Original Research
Reference values of fetal atrioventricular time intervals derive from antegrade late diastolic arterial blood flow (ALDAF) from 14 to 40 weeks of gestation
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1
Department of Obstetrics & Gynecology, Phramongkutklao Hospital, 10400 Bangkok, Thailand
2
Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), 12120 Pathumthani, Thailand
*Correspondence: nong-dan@hotmail.com (Thanakorn Heetchuay)
Clin. Exp. Obstet. Gynecol. 2021, 48(4), 867–874;
https://doi.org/10.31083/j.ceog4804137
Submitted: 20 November 2020 | Revised: 8 April 2021 | Accepted: 12 April 2021 | Published: 15 August 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Fetal echocardiography
Atrioventricular time
Congenital heart block
Pulse wave Doppler
Prenatal diagnosis
Figures
Fig. 1.