Background: To explore the effect of high-quality nursing model based on hope theory in endometrial cancer patients. Methods: The patients (n = 120) with endometrial cancer who underwent surgical treatment in hospital from October 2017 to October 2019 were divided into the study group and control group using the random number table method. The patients received usual care in the control group, and received high-quality nursing based on hope theory in the study group. Then, the degree of pain, fatigue, anxiety and depression were evaluated using visual analogue scale (VAS), chronic pain self-efficacy scale (CPSS), cancer fatigue scale (RPFS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS). The hope level and coping style were assessed using Herth hope scale (HHI) and summary coping style questionnaire (SCSQ). The quality of life was assessed using Medical Outcomes Study item short from health survey (SF-36). Moreover, nursing satisfaction was compared using homemade questionnaire. Results: The results showed that VAS score, RPFS score, SDS score and passive coping score of SCSQ questionnaire in the study group were lower than those in the control group (p 0.05). CPSS score, HHI score, positive coping score of SCSQ questionnaire, nursing satisfaction and SF-36 scores in all dimensions in the study group were higher than those in the control group (p 0.05). Discussion: The high-quality nursing model based on hope theory could ameliorate patients’ pain and fatigue, enhance their self-efficacy, guide patients to face problems positively, improve their life quality and hope level. Conclusion: It has higher nursing satisfaction in endometrial cancer.