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IMR Press / CEOG / Volume 48 / Issue 3 / DOI: 10.31083/j.ceog.2021.03.2460
Open Access Case Report
Prenatal ultrasonographic diagnosis of fetal scrotal inguinal hernia: a case report and literature review
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1 Department of Gynecologic Oncology, Medical University Pleven, 5800 Pleven, Bulgaria
2 Medical Center Vitality, 9000 Varna, Bulgaria
Clin. Exp. Obstet. Gynecol. 2021, 48(3), 723–727; https://doi.org/10.31083/j.ceog.2021.03.2460
Submitted: 9 January 2021 | Revised: 31 January 2021 | Accepted: 14 February 2021 | Published: 15 June 2021
Abstract

Background: Prenatal inguinoscrotal hernia is a rare condition and currently there are only several reports in the literature. Materials: We present a case of inguinoscrotal hernia in a 37-weeks’ gestation fetus, diagnosed at routine prenatal ultrasound. Surgical anomaly correction was done two months after Cesarian section in 39 weeks’ gestation. Results: We discussed the differential diagnosis of scrotal tumor formations that may occur prenatally. We performed a systematic literature review to provide useful information for the diagnosis and the management of this rare prenatal pathology. Discussion: Inguinoscrotal hernia occurs in both single or multifetal pregnancies with no side predilection; it does not mandate a change in the mode or time of delivery with recommendations for correction shortly after birth. Currently, there are no long-term follow-up data about fertility issues in fetuses with inguinoscrotal hernia in their adolescence.

Keywords
Inguinal hernia
Fetal ultrasound
Scrotal mass
Outcome
1. Introduction

Inguinal hernia is the most common anterior abdominal wall defect in newborn and children [1] with a reported rate of 1–4% [2]. It is an exclusively rare event prenatally because the intraabdominal pressure of the fetus is similar to the surrounding the fetus amniotic fluid [2]. Prenatally, inguinal hernia was first described in 1992 by Meizner et al. [1] during a 33-gestational-week male fetus. Since then, the cases, described in the literature, are very uncommon. We did a search in PubMed and Science Direct by the following keywords: fetal inguinoscrotal hernia, fetal scrotal hernia, fetal inguinal hernia, prenatal inguinoscrotal hernia, prenatal scrotal hernia, prenatal inguinal hernia. Only 17 publications were found with 18 reported cases. Among them, 17 publications are full-text reports and only one is published as an abstract We present a case report of a 31-year-old woman with her first pregnancy where the routine ultrasound examination describes a tumor mass in the right scrotum, diagnosed as an inguinal hernia.

2. Case report

A 31-year-old woman, diagnosed with her first pregnancy, was routinely followed via ultrasound (US). In 37th weeks’ gestation (g.w.), a routine US examination was done for routine fetal check-up. Until that moment, no abnormalities were reported in the clinical or US follow-up of the pregnancy and the patient. There were no abnormalities reported during the fetal morphological examination in the first, second or third trimesters therefore it was a normal fetal development. The US confirmed normally formed male genitalia with two US positive testes in the scrotal sac six weeks earlier—during 31st g.w. (Fig. 1).

The US examination visualized normal biometrical indices for the amenorrhea term; normal quantity of the amniotic fluid for the age of the pregnancy. The US in 37th g.w. described for the first time a tumor mass in the right scrotum with homogeneous ultrasound structure 36 $\times{}$ 37 mm with clearly defined margins and no vessels detected by Doppler US (Figs. 2-4). Peristalsis was not seen in the scrotal sac and only an US positive testis was visualized. The left scrotum presented with normal size and there was an US positive testis to the left. The midline of the testes was displaced to the left (Figs. 3,4). A diagnosis of right sided inguinoscrotal hernia was given.

Fig. 1.

Normal testes bilaterally during 31 g.w.

Fig. 2.

Tumor structure in the right testis during 37 g.w.

Fig. 3.

Homogeneous tumor structure (36 $\times{}$ 37 mm) in right testis, 37 g.w.

Fig. 4.

Tumor structure in the right testis in 37 g.w. with Doppler.

The fetus was delivered in the 39th g.w. via an emergency Caesarian section due to a birth arrest of the spontaneous labor. A male new born with body weight of 3290 grams and length of 51 cm was born with an Apgar score of 9 at the first minute and 10 at the fifth minute after delivery. Pediatric surgeon consulted the new born immediately after birth and confirmed the prenatal diagnosis of inguinoscrotal hernia to the right with no peristalsis or clinical data for incarceration (Fig. 5). The hernia was replaced manually. Further more, at the age of 2 months, the hernia persisted and was surgically corrected with no further complications. We obtained ICF from the mother of the newborn before this publication.

Fig. 5.

Asymmetrical presentation of the scrotum after birth.

3. Discussion

Inguinal hernia in children develops as a consequence of incomplete or defective closure of the processus vaginalis peritoniae [3-5]. This evolution takes place during or immediately after birth. In case this does not happen, the increase in the intraabdominal pressure of the newborn may lead to incarceration of an intestinal loop in the scrotum [3,4]. In about 20% of the newborns, the obliteration of processus vaginalis peritoniae does not occur immediately after birth, but at a later stage. Despite being uncommon, delayed obliteration may occur up to 1 year after birth [6]. The rate of this condition is increased in newborns with low birth at delivery and premature babies [7]. Anomalies, causing a higher intraabdominal pressure, such as vigorous cry, ascites, meconium peritonitis, chronic lung disease, bowel pathology and preterm delivery, may be relevant for the development of inguinal hernias due to an increase in the intraabdominal pressure [8].

The mechanism of development of prenatal scrotal inguinal hernia is not well known. Herniation of the bowel loops into the scrotum may occur concurrently with the testicular descent between the seventh and ninth month of gestation [9]. Routine prenatal US has been considered a safe and accurate tool for prenatal diagnostic in pregnant women. It allows for accurate determination of many fetal parameters and dynamic follow-up of the pregnancy. It may also find fetus- or mother-related conditions that could alter the follow-up or the subsequent obstetrical management. Whenever at US examination a scrotal formation is seen, a differential diagnosis with hydrocele, teratoma, hemangiomas, solid testis tumors, intestinal hernia or testis torsion should be discussed. Hydrocele is the most frequent reason [3]. The inguinal hernia is much more rarer and in order to diagnose it, several US criteria should be present: maternal gestational age not less than 26 weeks; scrotal mass with smooth contour and predominant solid content with internal echo-free cystic components, consistent with bowel loops; intestinal peristalsis within the scrotum at real-time US, with movement and deformation of the echo-free cystic components [2]. Typically, the diagnosis is given after 26th g.w. [10], but occasionally it may also be diagnosed earlier—e.g., in 23rd g.w. [7].

Most frequently, the scrotal inguinal hernia is a solitary anomaly. There are, though, reports of co-existing anomalies—rib and vertebral anomalies in the setting of Jarcho-Levin syndrome, lumbosacral myelomeningocele with Chiari malformation, D-transposition of the great arteries, multiple hemivertebrae, and lower extremities fixed in flexion with short longs bones and bilateral talipes [11].

As a rare condition, described in case reports there are no publications, focused on risk factors or the etiology of the condition. In order to compare available data, we summarized the characteristic of the patients, reported in the published case reports in Table 1 (Ref. [1,2,6-8,12-23]).

Table 1.Clinical characteristics of fetuses with inguinal hernia, diagnosed prenatally, the pregnancy and their mothers (Ref. [1, 2, 6, 7, 8, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23]).
 Author and year of publication Mother’s age Current pregnancy number Number of fetuses of the current pregnancy Gestational week at diagnosis Previous normal US before diagnosis Hernial side Method of delivery Prenatal abnormalities Fetal age at delivery Weight at delivery Outcome of the hernia Kithir Mohamed, 2015 [6] 22 1 1 37 22 Right VD Hydrocele 39 3050 Spontaneous regression Ronzoni et al., 2015 [12] 34 1 1 32 18 Right SC Dilated bowel loop low anorectal malformation 35 2230 g Surgical correction after 6 months Khatib et al., 2013 29 3 1 36 22 Bilateral VD No 39 3160 Surgical correction after 1 month [13] 25 2 1 24 NA NA NA No NA NA Surgical correction after 1 month Massaro et al., 2013 [2] 30 1 1 37 30 Right SC Hydrocele 39 3700 Surgical correction after 10 days Basaran et al., 2010 [14] 28 4 1 33 28 Left VD Spondylocostal dysostosis 40 2900 Died Frati et al., 2008 [15] 29 3 1 35 22 Right VD No 40 3650 Surgical correction after 4 days Bohlmann et al., 2008 [16] 38 2 1 34 21 Right VD Multiple congenital anomalies 35 NA NA Caserta et al., 2007 [7] 29 2 1 21 NA Right SC No 37 3300 Surgical correction in first week Eun-Kyung Ji et al., 2005 [17] 30 1 1 36 24 Left SC Left foot showed varus deformity 37 3200 Died Allen et al., 2004 [18] 26 NA 1 34 30 Left VD Cystic fibrosis NA 2676 Surgical correction after 3 weeks Sharma et al., 2004 [19] 30 1 3 34 21 Right SC No 36 2460 Surgical correction after 3 days Kesby et al., 1997 [8] 28 1 1 36 22 Right VD No 1 1 36 Paladini et al., 1996 [20] 26 1 1 30 NA NA VD Multiple congenital anomalies 37 2300 Died Shipp and Benacerraf, 1995 [21] 30 NA 1 40 NA Right VD Hydrocele 40 NA Surgical correction Hussain and Doiron, 1995 [22] 32 2 1 41 21 Bilateral SC No 41 4096 Surgical correction after 2 days Ober and Smith, 1991 [23] NA NA NA NA NA NA NA NA NA NA NA Meizner et al., 1991 [1] 21 1 1 33 NA Left VD No 40 3400 Surgical correction after 7 days Our case 37 1 1 37 31 Right SC No 39 3290 Surgical correction after 2 months

As a rare condition, summary and description of available data is essential. Of all inguinoscrotal hernias, bilateral localization is the most rarely seen in only 15%. If unilateral, the right-sided hernia is predominant (60%) and localized to the left side of the scrotum—in 25% [7]. The term or the method of delivery (vaginal or Cesarian section) does not depend if hernia is present or not. It is only defined by other patient’s, fetuses’ and pregnancy related factors. Most often, this anomaly is detected as a sole anomaly or related to a co-existing hydrocele; sometimes it may be co-existing with other congenital anomalies. It is discovered at a routine US examination, most often after 33 g.w. However it may also be discovered earlier as there are cases with diagnosis in 21st and 24th g.w. [7,13]. In our case despite undergoing previous multiple US examinations, the hernia was detected and diagnosed via US at a later stage of the pregnancy (37th g.w.). This highlights the importance of a high- quality US follow-up in dynamos, including control examination prior to the expected delivery. Inguinal hernia is seen in one fetus pregnancies with only one case in the literature, where it was diagnosed in the sole male fetus in a multifetal pregnancy [19]. This defect is corrected immediately after delivery or several weeks later. There are cases where the defect was operated later on after a longer interval. But surgical correction is the management of choice as spontaneous regression is rare and described in only one case [6].

In our case, the diagnosis was given in 37th g.w. with no other co-existing anomalies. This finding was incidental at a routine US and did not influence the obstetrical management of the pregnancy. As per local practices and decision of the surgeon, the operative correction was done after 8 weeks post-delivery. We searched the scientific literature and we found out that the recommended time for surgical correction is immediately after or soon after delivery. However, due to the rarity of this condition, there are currently no management guidelines.

Currently, there is no data about longer follow-up after delivery of these fetuses with inguinoscrotal hernia during pregnancy, in particular regarding potential fertility issues in their adolescence. We think this has to be changed.

4. Conclusions

The inguinoscrotal hernia is a rare prenatal condition, diagnosed incidentally via ultrasound. Typically it is diagnosed after 32nd gestational week and is a single anomaly, not related to congenital hereditary syndromes. The diagnosis of the hernia is given only after a differential diagnosis with other conditions and does not indicate or require a change in the delivery time or method. This is an anomaly that, optimally, is successfully corrected via surgery immediately or soon after delivery.

Author contributions

Conceptualization AY; methodology KZ; formal analysis AY; investigation AY; resources KZ; data curation KZ; writing—original and draft preparation AY; writing—review and editing KZ; visualization AY; supervision AY. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate

The patient gave informed consent for inclusion before she participated in the study.

The study was conducted in accordance with the Declaration of Helsinki Ethical Principles and Good Clinical Practices, and the protocol was approved by the Ethics Committee of Medical Center Vitality (approval number: Vit 05/20).

Acknowledgment

We would like to express my gratitude to all those who helped me during the writing of this manuscript.

Thanks to all the peer reviewers for their opinions and suggestions.

Funding

This research received no external funding.

Conflict of interest

The authors declare no conflict of interest.

Publisher’s Note: IMR Press stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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