Background: Assessing outcomes of birth in induced patients (full-term and premature) in relation with symphysis-fundal height (SFH) measurement. Methods: A prospective enrollment of induced patients was performed at the Obstetrics and Gynecology Unit of Arcispedale Sant’Anna of Ferrara. Reasons for induction, Bishop’s score, body mass index, gestational age, parity, mode of induction, number of induction cycles, time of active labor phase, Cesarean section, operative vaginal birth, post-partum hemorrhage, arterial cord pH, neonatal intensive care admission, size at birth were recorded. Correspondence analysis was applied to analyze independent relationships. These relationships were converted into probabilities. Probabilities for outcomes variables were plotted along with values of SFH and trends were tested. Results: Significant trends of increasing probability of adverse birth and labor outcomes were observed for SFH from 34 cm or less to over 37 cm: two cycles of induction (best fit p = 0.002); three cycles of induction (best fit p = 0.002); Cesarean section (best fit p = 0.027); higher length of active phase of labor (best fit p = 0.002); operative vaginal birth (best fit p = 0.002); arterial blood pH below or equal to 7.15 (best fit p = 0.006); post-partum minor hemorrhage (best fit p = 0.002), post-partum major hemorrhage (best fit p = 0.006). Conclusion: In induced pregnancies, SFH over 34 cm increased the probability of both neonatal and labor adverse outcomes, independently of gestational age.
In the last two decades, many efforts were undertaken to improve estimates of fetal birth size trough sonographic assessment. Customizing fetal chart biometry [1, 2], different formulas for calculating fetal birth weight [3], repeated measurements [4] or probabilistic models [5] have been suggested. Additionally, clinical evaluation of the symphysis-fundal height (SFH) has been tested for predicting both lower and higher birth sizes [6, 7]. While predicting fetal birth size is useful for timing of birth in both low and high birth babies, we have previously shown [8, 9, 10] that SFH can predict adverse delivery outcomes in both induced and non-induced labors, independently from fetal weight. These studies, however, only assessed the delivery outcomes in full-term pregnancies. The aim of the present short report is to assess outcomes of birth in induced patients, encompassing also patients not at term, according to SFH values.
A prospective enrollment of a sample of induced patients was performed from January to December 2019 at the Obstetrics and Gynecology Unit of Arcispedale Sant’Anna of Ferrara. SFHs were collected using a tape measure, from the upper rim of the symphysis to the bottom of uterus, with patient in gynecological position.
Reasons for induction (diabetes, hypertensive disorders of pregnancy,
intrahepatic cholestasis of pregnancy, oligohydramnios, intra-uterine growth
restriction (IUGR)—small for gestational age (SGA), premature rupture of
membranes (PROM), obesity, preventing post-maturity syndrome, other indications),
Bishop’s score, body mass index (BMI), gestational age, parity, mode of induction
were collected at the time of the first cycle of induction along with SFH. Number
of induction cycles was also collected in the succeeding days. Time of active
phase of labor was calculated as a ratio (R) between the time of initiation of
partograph to time of birth (expressed in minutes) out of dilatation value
(expressed in centimeters) at the time of partogram initiation. Delivery outcome
(Cesarean section, operative vaginal birth, post-partum hemorrhage (PPE)),
neonatal outcome (arterial cord pH, neonatal intensive care admission (NICU)),
birth size (
Intercorrelations among variables were expected. To cancel out the
intercorrelations, bi-dimensional correspondence analysis (symmetrical
normalization) was applied to find independent relationships among SFH classes
(
Probabilities were plotted according to outcome variables (upper quartile (UQ))
of R for the duration of active phase of labor, operative vaginal birth, Cesarean
section, minor PPE, major PPE, arterial cord pH, neonatal intensive care (NICU)
admission, two cycles of induction, three cycles of induction). Slopes were
tested in regression models to find significant fit (p
One-hundred-sixty-nine induced pregnancies were assessed. Inductions were
performed preterm, late preterm, early term, full term and late term for various
indications. Table 1 describes the samples. Fig. 1 depicts the results of
correspondence analysis. Red points represent the positions of SFH classes in
relation with other variables (blue points). The closer a blue point is to a red
point, the higher the association among the SFH class and that variable. For
example, the SFH
Age (mean |
32.5 | |
Gestational age (N, rate) | ||
-Preterm | 15, 8.9% | |
-Early term | 54, 32.0% | |
-Full term | 66, 39.1% | |
-Late term | 35, 20.7% | |
Parity (N, rate) | ||
-nullipara | 106, 62.7% | |
-multipara | 63, 37.3% | |
Body Mass Index (mean |
||
- |
141, 83.9% | |
- |
27, 16.1% | |
Indication for labor inducing (N, rate) | ||
-Intra-uterin growth restriction (IUGR) or Small for date (SGA) (N, rate) | 17, 10.1% | |
-Hypertensive disorders | 25, 14.8% | |
-Diabetes | 43, 25.4% | |
-Premature rupture of membranes | 42, 24.9% | |
-Late term gestational age | 29, 17.2% | |
-Obesity | 14, 8.3% | |
-Intrahepatic cholestasis of pregnancy | 4, 2.4% | |
-Olygohydramnios | 4, 2.4% | |
-Others | 17, 10.1% | |
Bishop’s score (N, rate) | ||
- |
143, 84.6% | |
- |
26, 15.4% | |
Method of first induction cycle of induction | ||
-Dinoprostone 10 mg vaginal delivery system | 23, 13.6% | |
-Oral misoprostol (50 mg four times) | 70, 41.4% | |
-Both misoprostol and mechanical induction (balloons) | 64, 37.9% | |
-Mechanical induction (balloons) | 4, 2.4% | |
-Oxytocin | 8, 4.7% | |
More than a cycle of induction | ||
-two cycles | 34, 20.1% | |
-three cycles | 135, 79.9% | |
Labour active phase duration (R)* (mean |
53.521 | |
Lower quartile (LQ) (N, rate) | 43, 25.4% | |
Normale range (NR) (N, rate) | 43, 25.4% | |
Upper quartile (UQ) (N, rate) | 83, 49.1% | |
Operative vaginal deliveries (N, rate) | 7, 4.1% | |
Cesarean section (N, rate) | 40, 23.7% | |
Arterial cord pH |
14, 10.4% | |
Neonatal intensive care unit (NICU) admission*** | 29, 18.0% | |
Fetal birth weight | ||
- |
12, 7.1% | |
-Appropriate birth weight (between 2500 g and 4000 g) | 136, 80.5% | |
- |
21, 12.4% | |
Post partum hemorrhage (N, rate)**** | ||
-minor | 29, 17.4% | |
-major | 4, 2.4% | |
Symphysis fundal height | ||
- |
37, 21.9%; 31.4 | |
-35 cm (N, rate) | 16, 9.5% | |
-36 cm (N, rate) | 21, 12.4% | |
-37 cm (N, rate) | 25, 14.8% | |
- |
26, 15.4%; 39.6 | |
*One case missing. **Thirty-five cases missing. ***Eight cases missing. ****Two cases missing. |
Outcome | Model | |||||
Linear | Logarithmic | Inverse | Quadratic | Power | Esponential | |
PPE minor | 0.066 | 0.053 | 0.041* | 0.002* | 0.062 | 0.077 |
PPE major | 0.036* | 0.027* | 0.020* | 0.006* | 0.048* | 0.060 |
Art. cord pH |
0.037* | 0.028* | 0.021* | 0.006* | 0.048* | 0.061 |
NICU | 0.158 | 0.136 | 0.117 | 0.055 | 0.099 | 0.117 |
Three cycles of induction | 0.078 | 0.063 | 0.051 | 0.002* | 0.068 | 0.084 |
Two cycles of induction | 0.080 | 0.065 | 0.052 | 0.002* | 0.069 | 0.085 |
Cesarean section | 0.126 | 0.106 | 0.089 | 0.027* | 0.088 | 0.105 |
Labour active phase duration over UQ for R | 0.070 | 0.056 | 0.044* | 0.002* | 0.064 | 0.079 |
Operative vaginal birth | 0.066 | 0.053 | 0.041* | 0.002* | 0.062 | 0.077 |
p values for regression models are reported. Regressions are built between SFH and probability of the outcome. The best fit is observed for the quadratic model of trend. *means significant results. |
Perceptual map of two dimensional correspondence analysis. *
marks the items as the reasons for induction. Variables are represented as points
and grouped in two sets: the red ones (SFH classes) and the blue ones (all other
variables assessed). The distances among points are reliable independent
estimates of their associations. The closer is a blue dot-point to a red-dot
point, the higher is the association. However, the Figure is only descriptive and
it does not used for inferential insights. SFH
Trends of birth outcomes according to SFH values. p values for each kind of trend assessed. On the y-axis probabilities are reported; on the x-axis SFH values are reported.
Findings of the present study confirm that SFH (over 34 cm) predicts adverse labor outcomes in induced pregnancies. Additionally, our study suggests that SFH is also able to predict some adverse neonatal outcomes. This study cannot assess if adverse outcomes are linked to a cause-effect relationship with gestational diseases rather than with SFH and its involvement in labor evolution. This is mainly due to communalities among each variables conditioning the outcomes. To assess the SFH association with adverse birth and neonatal outcomes, larger cohort of induced pregnancies should be analyzed, stratifying database for SFH values and comparing outcomes in multivariable models. This is hard to realize. Nevertheless, it is likely that diabetic or hypertensive patients at term with SFH below 34 cm are less likely to be at risk for adverse outcomes compared to diabetic or hypertensive patients with SFH over 34 cm for birth-size related concerns. Remarkably, the finding is poorly associated with neonatal birth weight below 2500 g or over 4000 g (Fig. 1). The results confirm that SFH cannot be used for predicting birth size [6, 7, 11, 12], leading to strengthen the hypothesis that SFH can predict the birth success [13, 14] by labor induction. Higher SFH values could be related with fetal head station, fetal head deflected positions, unstable positions and malpositions. Those can affect labor progression and onset at the beginning of induction and are not always linked with fetal birth size and Bishop’ score (Fig. 1), explaining associations with labor and birth worst outcomes.
In conclusion, SFH values could be useful for timing of induction as it links with birth and neonatal outcomes. As timing of birth is still a concern for patients with gestational diabetes, a randomized trial could be conducted to further examine the timing of induction in pregnancy affected by such a disease.
UI planned the study, analyzed data, wrote article; MGLM, BB, SC collected data and searched literature; MGLM also organized database; DM contributed to plan the study and to write article; PG supervised and gave interpretation to findings. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript.
The study was conducted in accordance with the Helsinki’ declaration and consents were obtained from the patients at the time of recovery.
We would like to express my gratitude to all those who helped me during the writing of this manuscript.
This research received no external funding.
The authors declare no conflict of interest.