Purpose of investigation: The prospects for effective cytological screening in the majority of developing countries are limited. This study evaluated visual inspection with acetic acid (VIA) for the diagnosis of CIN 2-3 in case findings. Materials and Methods: In this prospective study, 1437 asymptomatic women were screened using VIA followed by colposcopy-biopsy of all cases. The predictive efficacy of VIA was determined based on pathological confirmation of CIN 2-3 on colposcopy-directed biopsy. Results: In 388 (27%) out of 1437 cases, the VIA was positive. In 31 (2.1%) cases, CIN 2-3 was confirmed on cervical biopsy. The sensitivity, specificity and negative predictive value (NPV) of the VIA were 41.9%, 73.3%, and 98.2%, respectively. Conclusion: The present study confirmed the value of VIA for screening, with sensitivity of 41.9% and NPV of 98.2%. Future studies should determine the best place for VIA testing alongside other types of testing in screening algorithms.
Cite this article
Is visual inspection with acetic acid (VIA) a useful method of finding pre-invasive cervical cancer?
Maliheh Arab1,*, Atefeh Moridi2, Ghazaleh Fazli3, Robabeh Ghodssi-Ghasemabadi4, Maryam Maktabi5, Samaneh Saraeian6, Mahdie Sanati7
1 Gynecology-Oncology, Cancer Research Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran
2 Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran
3 Department of Developmental Biology, Science and Research University of Tehran, 1417466191 Tehran, Iran
4 Department of Biostatistics, Tarbiat Modares University, 14117-13116 Tehran, Iran
5 Obstetrics & Gynecology, Arak University of Medical Sciences, 38156879 Arak, Iran
6 Obstetrician & Gynecologist, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran
7 Developmental biology, Science and Research University of Tehran, 1417466191 Tehran, Iran
Clin. Exp. Obstet. Gynecol. 2021, 48(1), 128–131; https://doi.org/10.31083/j.ceog.2021.01.2209
Submitted: 4 July 2020 | Revised: 15 October 2020 | Accepted: 16 November 2020 | Published: 15 February 2021
Visual inspection with acetic acid