Purpose of Investigation: To investigate the alterations of SCUBE1 levels in patients with missed abortion. Materials and Methods: Patients with missed abortion (n = 40) and age and gestational age-matched with normal early pregnancy cases (n = 40) were recruited for the study. All the patients’ ultrasound examinations were performed by single physician to assess the variability of conception. And to evaluate the SCUBE1 levels, venous blood samples were collected and measured with specific enzyme-linked immunosorbent assays. Results: SCUBE1 levels were found lower at missed group than control group (p < 0.001) while other hematologic parameters were similar in both groups. Conclusion: Low maternal blood levels of the SCUBE1 may be related with missed abortion by causing alterations in placental angiogenesis.