IMR Press / CEOG / Volume 47 / Issue 6 / DOI: 10.31083/j.ceog.2020.06.5387
Open Access Systematic Review
Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials
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1 Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China
*Correspondence: daihuihua65@163.com (HUIHUA DAI); chengwenjundoc@163.com (WENJUN CHENG)
Clin. Exp. Obstet. Gynecol. 2020, 47(6), 821–828; https://doi.org/10.31083/j.ceog.2020.06.5387
Submitted: 13 September 2019 | Accepted: 28 May 2020 | Published: 15 December 2020
Copyright: © 2020 Sun et al. Published by IMR Press
This is an open access article under the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/.
Abstract

Background: The aim of this meta-analysis was to compare levonorgestrel intrauterine system (LNG-IUS) with oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection. Materials and Methods: Computerized literature search was performed in PubMed and several Chinese databases to screen for relevant trials. Quality assessment and meta-analysis were performed for the included trials. Results: A total of 19 randomized controlled trials were identified. Meta-analysis indicated that the LNG-IUS group was associated with lower recurrence rate of endometrial polyps than the oral progestin group (p < 0.0001), while there was no significant difference in the incidence of abnormal uterine bleeding between groups (p > 0.05). In terms of adverse effects related to progestin, the LNG-IUS group had significantly fewer adverse effects than the oral progestin group (p < 0.0001). Additionally, the LNG-IUS group had thinner endometrium and higher hemoglobin levels than the oral progestin group (p < 0.00001). Conclusion: The LNG-IUS was more effective and safer in preventing the recurrence of endometrial polyps after hysteroscopic resection than oral progestin.

Keywords
Endometrial polyps
Levonorgestrel intrauterine system
LNG-IUS
Oral progestin
Meta-analysis
Funding
2013, H201404, FRC201755/Research project of maternal and child health care in Jiangsu Province of China
81472442/the National Natural Science Foundation
Figures
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