Objective: This study aims to evaluate the delivery room data for patients who give birth with standard vaginal delivery and caesarean section (C/S), to estimate whether high-risk (HR) HPV status affected the mode of delivery. Methods: Between January 2014 and January 2018, 8,376 pregnant women gave birth in our hospital. Of 8,376 patients, 1,039 pregnant women were aged 30 years and older and had HPV results known. They had a singleton pregnancy and no contraindications for standard delivery. Results: C/S rates for all HR HPV groups were lower than for all HPV-negative groups. However, no statistically significant difference was found between HR HPV-positive and HPV-negative patients for C/S rates got all 987 patients (18.75% vs. 24.39%) (p = 0.463), 245 primiparous patients (50.0% vs. 59.83%) (p = 0.629) and 742 multiparous patients (11.53% vs. 12.56%) (p = 0.876). Conclusion: HR HPV positivity does not affect normal vaginal labour progress and does not statistically increase C/S rates at the labour ward. Therefore, HR HPV positivity should not be regarded as a negative risk factor for normal vaginal labour progress.