IMR Press / CEOG / Volume 47 / Issue 4 / DOI: 10.31083/j.ceog.2020.04.5308
Open Access Original Research
High fibrin/fibrinogen degradation product and D-dimer levels for the diagnosis of invasive group A streptococcal infections during pregnancy
Show Less
1 Matsumoto Women’s Health Clinic, Saitama, Japan
2 Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan
*Correspondence: research@matsumotoc.org (NAOKI MATSUMOTO)
Clin. Exp. Obstet. Gynecol. 2020, 47(4), 483–489; https://doi.org/10.31083/j.ceog.2020.04.5308
Submitted: 27 June 2019 | Accepted: 23 September 2019 | Published: 15 August 2020
Copyright: © 2020 Matsumoto and Mori. Published by IMR Press.
This is an open access article under the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/.
Abstract

Objective: Invasive group A streptococcal (GAS) infections during pregnancy are uncommon, and, thus, their early diagnosis remains challenging. The present study was performed to assess fibrin/fibrinogen degradation product (FDP) and D-dimer levels in pregnant women with invasive GAS infections and establish whether they contribute to a diagnosis. Materials and Methods: Laboratory data, including FDP and D-dimer levels, measured between fulmination and just before delivery in 46 cases, consisting of 45 previously published cases and the present case, were examined. Results: Fetal/neonatal and maternal mortality rates were 61 and 28%, respectively. Laboratory data obtained from 24 cases just before delivery were as follows: white blood cell count ≥ 12,000/µL, 46% of cases; platelet count ≤ 100,000/µL, 55% of cases, and C-reactive protein (CRP) level ≥ 10 mg/dL, 40% of cases. These variables showed no sensitivity for the diagnosis of invasive GAS infections. However, 100% of cases were positive for FDP (≥ 10 µg/dL) and D-dimer (≥ 2 µg/dL), the levels of which were extremely high in many cases. Conclusion: FDP and D-dimer levels may contribute to the diagnosis of invasive GAS infections during pregnancy.

Keywords
Antepartum
Disseminated intravascular coagulation
Sepsis
Streptococcus pyogenes
Toxic shock syndrome
Figures
Figure 1.
Share
Back to top