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Recurrent hydatidiform mole: when to stop?
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1
Department of Obstetrics and Gynecology, Acibadem University School of Medicine, Istanbul, Turkey
2
Diagnostics Center for Genetic Diseases, University of Trakya, Trakya Medical Faculty, Edirne, Turkey
*Correspondence: esraizmit@gmail.com (ESRA OZBASLI)
Clin. Exp. Obstet. Gynecol. 2020, 47(3), 424–426;
https://doi.org/10.31083/j.ceog.2020.03.5215
Submitted: 4 March 2019 | Accepted: 4 June 2019 | Published: 15 June 2020
Copyright: © 2020 Ozbasli et al. Published by IMR press.
This is an open access article under the CC BY 4.0 license
https://creativecommons.org/licenses/by/4.0/.
Abstract
Recurrent hydatidiform mole (RHM) is defined as two or more repeated molar pregnancies in the same patient. Familial recurrent hydatidiform mole (FRHM) is a rare condition in which the patient has relatives with the same condition and mutations. Maternal mutations in the NLRP7 gene are mostly observed in RHM. The authors report a patient from Turkey with a history of seven molar pregnancies who had an aunt with similar obstetric history and NLRP7 mutations.
Keywords
Familial hydatidiform mole
NLRP7
Ovum donation
Genomic imprinting