IMR Press / CEOG / Volume 47 / Issue 3 / DOI: 10.31083/j.ceog.2020.03.5121
Open Access Original Research
Perinatal outcome of fetuses with echogenic intracardiac focus
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1 Derince Research and Education Hospital, Department of Obstetrics and Gynecology, Kocaeli, Turkey
2 University of Çukurova, School of Medicine, Department of Obstetrics and Gynecology, Perinatology Unit, Adana, Turkey
*Correspondence: (MEHMET ÖZSÜRMELI)
Clin. Exp. Obstet. Gynecol. 2020, 47(3), 372–375;
Submitted: 12 December 2018 | Accepted: 4 March 2019 | Published: 15 June 2020
Copyright: © 2020 Özsürmeli et al. Published by IMR press.
This is an open access article under the CC BY 4.0 license

Objective: Echogenic intracardiacs focus (EIF), a microcalcification of the papillary muscles in either or both ventricles of the fetal heart, is one of the more common ultrasonographic soft markers of trisomy 21. This study aimed to determine the relationship of EIF with trisomies in the presence of various ultrasonographic findings. Materials and Methods: A retrospective study of second-trimester obstetric sonograms (18-24 weeks) was conducted at a tertiary care center over a two-year period. The patients were divided into three groups: isolated EIF (group 1), EIF with at least one soft marker (group 2), and EIF with structural anomalies (group 3). All the groups were divided into subgroups on the basis of a screening test (maternal age ≥ 35, positive combined-triple-quadruple tests). The incidence of chromosome anomalies was evaluated. Results: The authors examined 8,300 patients during the study period and found 170 fetuses with isolated EIF (group 1), 26 fetuses with EIF and soft markers (group 2), and 37 fetuses with EIF and structural anomalies (group 3). Thirteen (8%) patients underwent fetal karyotyping in group 1, 10 (38%) in group 2, and 22 (60%) in group 3. The rate of the invasive test was higher in fetuses exhibiting EIF accompanied by at least one of the soft markers. No trisomy was detected in group 1 or 2. Conclusion: The risk of aneuploidy did not increase in either isolated EIF or in cases with other soft markers but only in cases with structural anomalies.

Prenatal ultrasonography
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