IMR Press / CEOG / Volume 47 / Issue 3 / DOI: 10.31083/j.ceog.2020.03.4946
Open Access Case Report
Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome
D. Lu1,†D. Cao2,†Q. Zhao3,†X. Chen2,*
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1 Department of Clinical Laboratory, Women and Children’s Hospital of Hubei Province, Wuhan, Hubei, P.R. China
2 Department of Obstetrics; Women and Children’s Hospital of Hubei Province, Wuhan, Hubei, P.R. China
3 Department of Clinical Laboratory, Dongsheng Area People’s Hospital, Ordos, Inner Mongolia, P.R. China
*Correspondence: bioxia@163.com (XIANGYI CHEN)
Contributed equally.
Clin. Exp. Obstet. Gynecol. 2020, 47(3), 427–428; https://doi.org/10.31083/j.ceog.2020.03.4946
Submitted: 17 July 2018 | Accepted: 4 February 2019 | Published: 15 June 2020
Copyright: © 2020 Lu et al. Published by IMR press.
This is an open access article under the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/.
Abstract

We report a case of prenatal diagnosis of mosaicism for chromosome t (7; 14) with a favorable fetal outcome. Similar chromosomal abnormalities have been observed in patients with hematologic malignancy. Chromosomal microarray analysis (CMA) revealed no genomic imbalance, prenatal ultrasound examination revealed no intrauterine growth restriction (IUGR) or dysmorphisms in this fetus. Therefore, combination of karyotype analysis, CMA, genetic counseling and prenatal ultrasound will prove a more specific risk evaluation for chromosomal translocation and mosaicism.

Keywords
Karyotype analysis
CMA
Chromosome translocation
Mosaic
Hematologic malignancy
Prenatal diagnosis
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