IMR Press / CEOG / Volume 47 / Issue 2 / DOI: 10.31083/j.ceog.2020.02.5235
Open Access Original Research
Pregnancy outcomes in women with congenitally corrected transposition of the great arteries
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1 Department of Obstertrics and Gynecology, Medical Center of Severe Cardiovascular of Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P.R. China
2 Department of Cardiac Surgery, Medical Center of Severe Cardiovascular of Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P.R. China
Clin. Exp. Obstet. Gynecol. 2020, 47(2), 291–295; https://doi.org/10.31083/j.ceog.2020.02.5235
Published: 15 April 2020
Abstract

The aim of this study was to define the pregnancy outcomes in women with congenitally corrected transposition of the great arteries (cc-TGA). The medical databases at Anzhen Hospital between January 2011 and March 2018 were retrospectively reviewed. Data of 12 pregnant women with cc-TGA were collected. One patient was lost at 35 weeks of gestation. There were 8 (72.7%) term births and 3 (27.3%) premature births. Of the 11 deliveries, 2 (18.2%) were vaginal and 9 (81.8%) were cesarean. The baseline New York Heart Association (NYHA) functional class was I - II in 11 patients, II - III in 7 patients, and III - IV in 5 patients in the third trimester (P = 0.037). In the third trimester, 6 (50%) patients became symptomatic and experienced heart function deterioration compared with asymptomatic patients (6 vs. 0, P = 0.002). In the third trimester, tricuspid regurgitation (TR) was identified in 11 patients: 2 with mild TR, 4 with moderate TR, and 5 with severe TR. Five symptomatic patients developed severe TR, in which the rate of TR was significantly higher than that of asymptomatic patients (5 vs. 0, P = 0.015). No difference was found in NYHA class between the third trimester and 1 week after delivery (P > 0.05). One patient died of ventricular fibrillation at 3 months postpartum. Successful pregnancy can be achieved by most women with cc-TGA. The deterioration of right ventricular function is common among pregnant women with cc-TGA, and severe TR is a high risk factor resulting in deterioration of the right ventricular function.

Keywords
pregnancy
congenitally corrected transposition of the great artery
systemic right ventricle
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