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OEIS complex (omphalocele-exstrophy-imperforate anus-spinal defects) in monozygotic twins: a case report and literature review
Y. Q. Xu1, X. L. Chen2, S. Zhao2, P. W. Chen2, X. M. Yin1, S. Y. Xiong1, Z. Ding3, F. Xiong4, X. H. Yang2,*
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1
Department of Ultrasound, Baoan Central Hospital of Shenzhen/The 5th affiliated hospital of Shenzhen University Health Science Center, 60 Xixiang Leyuan Street, Baoan district, Shenzhen, 518102, P.R. China
2
Department of Ultrasound, Hubei Women and Children’s Hospital, 745 Wuluo Road, Wuhan, Hubei 430070, P.R. China
3
The Institute of Metabolic Diseases, Baoan Central Hospital of Shenzhen/The 5th affiliated hospital of Shenzhen University Health Science Center, 60 Xixiang Leyuan Street, Baoan district, Shenzhen, 518102, P.R. China
4
Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, P.R. China
*Correspondence: yangxiaohong123@163.com (XIAO-HONG YANG)
Clin. Exp. Obstet. Gynecol. 2020, 47(2), 154–158;
https://doi.org/10.31083/j.ceog.2020.02.5141
Published: 15 April 2020
Copyright: © 2020 Xu et al. Published by IMR Press.
This is an open access article under the CC BY-NC 4.0 license
(https://creativecommons.org/licenses/by-nc/4.0/).
Abstract
The omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex represents severe midline abdominal and pelvic defects of unknown etiology. This complex is rare, affecting 1 in 200,000 to 400,000 pregnancies and is extremely rare in twin or triplet gestations. Here, we report the OEIS complex in a spontaneous monozygotic twin pregnancy and previously reported OEIS complex in twin or triplet pregnancy are reviewed. Spontaneous pregnancy and unremarkable family history, but concordance of monozygotic twins for the defect may support the theory that early malformation complexes, e.g., OEIS, may be related to errors in monozygotic splitting in early blastogenesis.
Keywords
Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS)
Twin pregnancy
Funding
WJ2018-H0148/Hubei Province health and family planning scientific research project
Figures
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