Aim: A missense mutation in the elastin gene (g28197A > G) is associated with an increased risk for inguinal hernias. Due to the shared epidemiological and pathophysiological features between pelvic organ prolapse (POP) and inguinal hernias, the authors hypothesized that a similar association exists between elastin gene polymorphism and POP. Materials and Methods: Patients of Ashkenazi Jewish origin with advanced (stage III-IV) POP (as assessed by POP-Q) and healthy controls were compared for the presence of the elastin gene g28197A > G missense mutation. Results: The missense mutation in the elastin gene was not found in neither the study or the control group. Conclusion: The elastin gene g28197A > G missense mutation was not found to be associated with an increased risk for POP.
Cite this article
Elastin genetic point mutation and the risk of pelvic organ prolapse
1 Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion University, Haifa, Israel
2 Faculty of Natural Sciences, University of Haifa, Israel
*Correspondence: firstname.lastname@example.org; email@example.com (I FEFERKORN)
Clin. Exp. Obstet. Gynecol. 2020, 47(1), 75–78; https://doi.org/10.31083/j.ceog.2020.01.5100
Published: 15 February 2020
Copyright: © 2020 Haya et al. Published by IMR press.
This is an open access article under the CC BY-NC 4.0 license
Pelvic organ prolapse