IMR Press / CEOG / Volume 47 / Issue 1 / DOI: 10.31083/j.ceog.2020.01.5023
Open Access Original Research
Is laser-assisted hatching better than mechanical method for enhancing pregnancy rate in frozen-thawed blastocyst transfer cycles?
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1 Departments of Obstetrics and Gynecology, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea
2 Infertility Center, Pusan National University Hospital, Busan, Korea
3 Departments of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea
*Correspondence: (K. S. Lee)
Clin. Exp. Obstet. Gynecol. 2020, 47(1), 65–69;
Published: 15 February 2020
Copyright: © 2020 Lee et al. Published by IMR press.
This is an open access article under the CC BY-NC 4.0 license

Objective: To investigate the effect of laser-assisted hatching (LAH) compared with mechanical-assisted hatching (MAH) for enhancing clinical outcomes in frozen-thawed blastocysts (FTBs) transfer cycles. Materials and Methods: The culture of all pronucleate embryos to the blastocyst stage and the selection of blastocysts ≥ grade 3BB (Gardner and Schooleraft score), followed by FTBs transfer cycles with LAH (n=105) or with MAH (n=101). Clinical outcomes including clinical and ongoing pregnancy rates were investigated.Results: There were no significant differences in clinical and ongoing pregnancy rates between LAH and MAH groups in FTBs transfer cycles. Conclusion: LAH does not improve pregnancy outcomes significantly compared to MAH in FTBs transfer cycles.

Laser-assisted hatching
Mechanical-assisted hatching
Frozen-thawed blastocyst
Figure 1.
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