IMR Press / CEOG / Volume 47 / Issue 1 / DOI: 10.31083/j.ceog.2020.01.4963
Open Access Original Research
Influence of cytokines on the postoperative period
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1 Department of Anesthesiology and Reanimatology, Clinical Centre "Kragujevac", Kragujevac, Serbia
2 Department of Clinical Pharmacology, Clinical Centre "Kragujevac", Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia
3 Department of Immunology, Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia
4 Department of Physiology, Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia
5 University IM Sechenov, Department of Human Pathology, 1st MOSCOW State Medical, Moscow Russian Federation, Serbia
*Correspondence: (D. JOVANOVIC)
Clin. Exp. Obstet. Gynecol. 2020, 47(1), 31–36;
Published: 15 February 2020
Copyright: © 2020 Jovanovic et al. Published by IMR Press.
This is an open access article under the CC BY-NC 4.0 license

Purpose of Investigation: The relationships between postoperative recovery and changes of circulating levels of pro- and anti-inflammatory cytokines. Materials and Methods: The study included prospectively a cohort of 51 females who underwent abdominal hysterectomy for benign diseases. Recovery was assessed with Quality of Recovery 40 (QoR-40) questionnaire and concentrations of four cytokines during the 72-hours period were measured using human sensitive enzyme-linked immunosorbent assay (ELISA) kits. Results: Total QoR-40 score significantly declined on the first and the second postoperative days and then returned to baseline (p < 0.001). Interleukin-17 serum levels had no significant trend (p = 0.072). Statistically significant patterns of concentration changes of interferon gamma (p = 0.010), interleukin-10 (p < 0.001), and transforming growth factor (p = 0.016) were found. There were no significant correlations between QoR-40 scores and concentrations of any cytokine, at prespecified study power for moderate relationships at least. Conclusion: Recovery after abdominal hysterectomy was rapid and complete and it was unrelated to serum concentration profiles of examined cytokines.

Postoperative recovery
Functional rehabilitation
Figure 1.
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