Spontaneous heterotopic triplet pregnancy (HTP) was formerly considered to be extremely rare. Recently, the broad use of assisted reproductive techniques to assist infertile couples, has contributed to the constant rise of non-spontaneous heterotopic triplets. A case of 38-year-old woman who underwent in vitro fertilization (IVF) and intracytoplasmatic sperm injection (ICSI) is presented. A series of complications appeared and were treated successfully. Although this situation could be life threatening and should alert the medical community, misdiagnosis is still present. The clinicians need to be aware that after IVF procedures, one or more complications might occur. In those cases, early diagnosis and surgical or conservative intervention is of paramount importance.