IMR Press / CEOG / Volume 46 / Issue 6 / DOI: 10.12891/ceog4801.2019
Open Access Original Research
Hereditary thrombophilia in the puerperiu a retrospective review of 11 cases complicated by cerebral venous thrombosis
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1 Department of Obstetrics and Gynecology, Faculty of Medicine, "Gr.T.Popa" University of Medicine and Pharmacy, Iasi, Romania
2 “Cuza Vodă” University Hospital, Iasi, Romania
3 “Saint John” Emergency Hospital, Suceava, Romania
Clin. Exp. Obstet. Gynecol. 2019, 46(6), 897–902; https://doi.org/10.12891/ceog4801.2019
Published: 10 December 2019
Abstract

Purpose of Investigation: The purpose of this study was to conduct a multidisciplinary analysis of a 11 cases of cerebral venous thrombosis in the puerperium associated with hereditary thrombophilia. Materials and Methods: The medical records of patients with ereditary thrombophilia and cerebral venous thrombosis in the puerperium were reviewed retrospectively. Clinical suspicion of cerebral venous thrombosis had been confirmed by CT or MRI. Results: Only in 11 cases the authors found the association between hereditary thrombophilia and cerebral thrombosis. The evaluation of the thrombophilic profile revealed that MTHFR C677T in combination with Factor V Leiden G1691A and Prothrombin G20210A were the commonest gene defects among cases studied. Conclusion: Hereditary thrombophilia may increase the risk of cerebral venous thrombosis in the puerperium.

Keywords
Thrombophilia
Pregnancy
Cerebral thrombosis
CT
MRI
Figures
Figure 1.
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