Purpose of Investigation: To examine if the potential changes in progesterone (P) and estradiol (E2) levels during the luteal phase can predict the outcome in IVF/ICSI cycles. Material and Methods: A prospective study of 282 patients with infertility undergoing IVF/ICSI have been included. Serum E2 and P measurements at day of hCG triggering and days 6 and 10 after embryo transfer in conception and non-conception cycles. Results: The ROC curve in predicting clinical pregnancy was calculated at 0.864 (95% CI: 0.841-0.92). A maximum reduction of ≤ 32 % demonstrated sensitivity of 84.3% and specificity of 80.4%. The corresponding ROC curve for percentage change in P levels was 0.733 with 95% CI: 0.334-0.96. Conclusion: A maximum reduction of 32 % in E2 levels between days 6 and 10 after embryo transfer demonstrated a predictive ability for clinical pregnancy after IVF/ICSI of 86.4% with sensitivity 84.3% and specificity 80.4%.
Cite this article
Luteal phase progesterone and estradiol concentrations and their relation to the outcome of IVF/ICSI cycles with controlled ovarian stimulation
1 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens, Greece
2 3rd Department of Obstetrics and Gynecology, Attiko Hospital, University of Athens, Athens, Greece
Clin. Exp. Obstet. Gynecol. 2019, 46(5), 727–730; https://doi.org/10.12891/ceog4741.2019
Published: 10 October 2019
Controlled ovarian stimulation