Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Purpose of Investigation: To examine if the potential changes in progesterone (P) and estradiol (E2) levels during the luteal phase can predict the outcome in IVF/ICSI cycles. Material and Methods: A prospective study of 282 patients with infertility undergoing IVF/ICSI have been included. Serum E2 and P measurements at day of hCG triggering and days 6 and 10 after embryo transfer in conception and non-conception cycles. Results: The ROC curve in predicting clinical pregnancy was calculated at 0.864 (95% CI: 0.841-0.92). A maximum reduction of ≤ 32 % demonstrated sensitivity of 84.3% and specificity of 80.4%. The corresponding ROC curve for percentage change in P levels was 0.733 with 95% CI: 0.334-0.96. Conclusion: A maximum reduction of 32 % in E2 levels between days 6 and 10 after embryo transfer demonstrated a predictive ability for clinical pregnancy after IVF/ICSI of 86.4% with sensitivity 84.3% and specificity 80.4%.