IMR Press / CEOG / Volume 46 / Issue 5 / DOI: 10.12891/ceog4711.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Preliminary analysis of risk factors for congenital heart disease: a retrospective review of 145 cases in a single institution
Show Less
1 Ultrasound Department, China Panyu He Xian Memorial Hospital, Guangzhou, China
2 Guangzhou Huayin Medical Labratory Center CO. Ltd, Guangzhou, China
*Correspondence: (QIANHONG LIANG)
Clin. Exp. Obstet. Gynecol. 2019, 46(5), 713–722;
Published: 10 October 2019

Background: Congenital anomaly is one of the most common cause of infant mortality and in China the incidence is quite high compared to other countries. It is therefore important to identify the potential risk factors of congenital problem such as congenital heart diseases. Materials and Methods: A retrospective study of 5,636 newborn cases from 2012 to 2014 in Panyu Maternal and Child Care Service Centre of Guangzhou was carried out, and among which 145 cases were confirmed for congenital heart defects. Review and analysis of maternal and paternal factors was performed using univariate and multivariate logistic regression analyses. Results: Several maternal factors were significantly associated with the occurrence of the congenital anomaly. However, after combining both maternal and paternal factors, only higher maternal age (OR = 1.076, 95% CI: 1.007-1.148, p = 0.029) and increased gravidity (OR = 1.153, 95% CI: 1.024-1.298, p = 0.018) were identified as risk factors whereas RBC count (OR = 0.374, 95% CI: 0.187-0.745, p = 0.005) was identified as a protective factor of the abnormal outcome using multivariate regression analysis. Conclusion: Further investigation on how the level of RBC in mother may contribute to the prevention of congenital heart disease is warranted.

Congenital heart disease
Regression analysis
Maternal factor
Paternal factor
Retrospective analysis
Red blood cell count
Back to top