Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
During embryonic development, both glandular parenchyma of prostate in a male fetus and paraurethral Skene’s glands in a female fetus develop from pelvic urethra endoderm. This common embryological origin results in finding prostatic tissue even in the lower genital tract in women. Herein, the authors present a case of polypoid lesion in vagina consisting solely of glandular elements without squamous component, which stained negative for prostatic markers, but morphologically identical to normal prostatic tissue. A patient, 57-years-old came to the Clinic, with a cystic change in the petiole, which size being 30×17×15 mm, on the left vaginal wall adjacent to introitus. The cystic change was excised and a preparation was sent to a histopathological examination. The histopathological examination included serial Hematoxylin and Eosin stained sections, along with immunohistochemical panel. It was concluded that it was ectopic prostatic tissue or ectopic paraurethral gland tissue within vaginal mucosa. Partially, epithelium at the surface of our polypoid lesion showed immature squamous metaplasia, vaginal intraepithelial neoplasia - VaIN II/III, and transitional cell metaplasia. Gland formations having benign features were within base of the change, at the resection lines, while dysplastic epithelium was fully removed.