IMR Press / CEOG / Volume 45 / Issue 6 / DOI: 10.12891/ceog4222.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
Anti-NMDAR encephalitis with pregnancy: a rare case report and literature review
Ruiqi Duan1, 3, †Xiumei Xu2, 3, †, *
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1 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
2 ICU of Gynecology & Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
3 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, No. 20, 3rd section, Chengdu, China
† These authors contributed equally to this work.
Clin. Exp. Obstet. Gynecol. 2018, 45(6), 949–951;
Published: 10 December 2018
Introduction: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder that has been recently reported. Its pathogenesis has been uncertain up until now. To date, it has been seen to very rarely occur during pregnancy and delivery, and there are no established guidelines for its treatment in clinical practice. Here the authors report a rare case of a 24-year-old pregnant woman with anti-NMDAR encephalitis that occurred in the third trimester. After a positive treatment response, the outcomes of both the mother and baby were satisfactory. To the best of the present authors’ knowledge, this is the first report on anti-NMDAR encephalitis occurring in the third trimester worldwide. This rare case enriches the sparse literature on anti-NMDAR encephalitis during pregnancy and could play a significant role in the diagnosis and treatment of such a disorder when seen in clinical practice. Therefore, the authors have documented their experience in dealing with such a disorder and briefly reviewed previously reported cases on this disorder and its occurrence during pregnancy.
Anti-N-methyl-D-aspartate receptor
Autoimmune disorder
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