Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Intravenous Immunoglobulin (IVIg) is a potential treatment for immune mediated reproductive failure (IMRF), but its role in infertility treatments remains controversial. There is evidence that administering IVIg before conception improves pregnancy outcomes. In the present cohort, 13/15 (86%) patients had a live birth after receiving pre-conceptual IVIg at immunomodulatory doses. No serious maternal or fetal side effects directly attributable to IVIg were reported. The present results support the need for a randomized controlled trial (RCT) with this protocol.