Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
† These authors contributed equally.
The present authors report an exceptional complex chromosomal rearrangement involving five chromosomes. Cytogenetic analysis of cultured amniocytes revealed a unique karyotype of 46,X,t(X;13;9)(q13;q14;p22),t(3;6)(p13;q23) in 35/35 cultured amniocytes. Microarray- based comparative genomic hybridization (aCGH) revealed two microdeletions on chromosome Xq13.1-q13.2 and 13q14.2- q21.1 respectively. This study demonstrates the feasibility of using aCGH for prenatal diagnosis, especially in detecting subtle chromosomal abnormalities in high risk pregnancies.