IMR Press / CEOG / Volume 45 / Issue 5 / DOI: 10.12891/ceog4304.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Vascular endothelial growth factor genetic polymorphisms at +405C/G and -460 C/T and the association with advanced stages of endometriosis
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1 2nd Obstetrics and Gynecology Department,“Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Clin. Exp. Obstet. Gynecol. 2018, 45(5), 725–730; https://doi.org/10.12891/ceog4304.2018
Published: 10 October 2018
Abstract

Purpose of investigation: Endometriosis is a common gynecologic disease, with a genetic component, a series of studies involving different vascular endothelial growth factor (VEGF) genetic variants in endometriosis pathogenesis. In this study, the authors aimed to describe the presence of VEGF genetic polymorphisms in relationship with endometriosis, to evaluate their relationship with VEGF serum levels, and to investigate its impact on endometriosis susceptibility. Materials and Methods: The authors studied the frequency of alleles, genotypes, and haplotypes of VEGF +405 C/G and -460 C/T genetic polymorphisms in patients with endometriosis, by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: This study did not find any significant relationship between the presence of mutant allele and endometriosis. Regarding VEGF serum levels and the presence of a different allele, there was also no statistically significant difference. Conclusion: This research shows that VEGF +405 C/G and -460 C/T genetic polymorphisms are not associated with advanced endometriosis, and VEGF serum levels did not correlate significantly in relationship with the presence of a different allele and/or genotypes, thus suggesting no involvement for this polymorphism in the pathogenesis of endometriosis.
Keywords
Endometriosis
Genetic polymorphism
Infertility
Angiogenesis
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