IMR Press / CEOG / Volume 45 / Issue 4 / DOI: 10.12891/ceog4348.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Associations between serum levels of adiponectin and resistin and metabolic parameters in pregnant women with gestational diabetes mellitus
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1 Department of Obstetrics and Gynecology, Karabuk Training and Research Hospital, Karabuk, Turkey
2 Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Inonu, Malatya, Turkey
3 Department of Biochemistry,Faculty of Medicine, The University of Fırat, Elazig, Turkey
4 Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Fırat, Elazig, Turkey
Clin. Exp. Obstet. Gynecol. 2018, 45(4), 539–543; https://doi.org/10.12891/ceog4348.2018
Published: 10 August 2018
Abstract

Introduction: Gestational diabetes mellitus (GDM) is defined as a glucose intolerance firstly diagnosed during pregnancy. In this study, the authors aimed to investigate the association between serum adiponectin, and resistin levels with insulin resistance and metabolic parameters in patients with GDM. Material and Methods: A total of 80 patients: 40 healthy pregnant women (control group) and 40 pregnant women diagnosed with GDM (study group) were included in this study. Serum adiponectin, resistin, glucose, insulin, HbA1c levels, and lipid parameters were measured. Insulin resistance index HOMA-IR values were calculated. Results: Serum adiponectin levels were detected to be significantly lower (p < 0.001), whereas serum resistin levels were found to be significantly higher (p = 0.004) in GDM group compared with the control group. Levels of HDL-C, LDL-C, VLDL-C, and triglycerides were similar in both groups, but the total cholesterol level was significantly higher in the GDM group (p = 0.013). In the GDM group, adiponectin levels were negatively correlated with HbA1c levels (r = -0.368; p = 0.010) but were not correlated with any other parameter. A significant positive correlation was evident between resistin levels and both total cholesterol (r = 0.476, p = 0.001), and LDL-cholesterol (r = 0.293; p = 0.033). Conclusion: The results of this study demonstrated that serum resistin levels were significantly higher and serum adiponectin levels were significantly lower in pregnant women with GDM patients compared with normoglycemic pregnants. Also, it was detected that there was no correlation between serum adiponectin and resistin levels and insulin resistance in GDM patients.
Keywords
Adiponectin
Gestational diabetes mellitus
Insulin resistance
Resistin
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