IMR Press / CEOG / Volume 45 / Issue 4 / DOI: 10.12891/ceog4189.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Downregulated osteopontin in placenta affects MMPs expression of trophoblastic cells
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1 Reproductive Medicine Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2 General Surgery Department, The Fourth Affiliated Hospital of Gangzhou Medical University, Guangzhou, China
3 Fatal Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

† These authors contributed equally.

Clin. Exp. Obstet. Gynecol. 2018, 45(4), 558–562; https://doi.org/10.12891/ceog4189.2018
Published: 10 August 2018
Abstract

Trophoblastic invasion plays a critical role in placental development. Shallow of invasion could cause the abnormal placentation which may probably resulted in preeclampsia (PE). Extracellular matrix (ECM) proteins are confirmed to mediate cell adhesion, migration, and invasion. Osteopontin (OPN) is a kind of ECM protein and has been found to be involved in invasion and metastasis of several types of cancers. The authors hypothesize that OPN could probably regulate trophoblastic cell invasion. Here, the results showed that the expression level of OPN significantly decreased in the placenta of PE. Furthermore the authors found that OPN-siRNA interference significantly decreased the expression of MMP-2, MMP-9 in villous explant, a crucial signaling molecule of trophoblast invasion. The findings suggest that OPN is a critical ECM protein for regulating trophoblastic cell invasion.
Keywords
Osteopontin
Trophoblast
Invasion
Villous explant
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