Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
The early diagnosis of preeclampsia (PE) remains one of the great medical problems worldwide. PE is a multisystemic disorder and the etiology is still unclear. The equilibrium between anti-angionenic and angiogenic factors is essential in the PE pathogenesis. In this review, the authors highlight the role of key circulating anti-angionenic and antiangiogenic factors as pathogenic biomarkers and as well as early diagnostic biomarkers for PE. They analyzed the main anti-angiogenic factors: soluble FMS–like tyrosine kinase (sFlt-1), soluble endoglin (sEng), and the angiogenic factors – vascular endothelial growth factor (VEGF) and placental growth factor (P1GF). An accurate algorithm for diagnosing PE using only biomarkers is still absent.