IMR Press / CEOG / Volume 45 / Issue 4 / DOI: 10.12891/ceog3951.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Non-invasive prenatal screening for chromosome 21, 18, and 13 aneuploidies in a mixed risk factors pregnancy population
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1 Center for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, China
2 CapitalBio Genomics Co., Ltd., Dongguan, China

†These authors contributed equally.

Clin. Exp. Obstet. Gynecol. 2018, 45(4), 523–528; https://doi.org/10.12891/ceog3951.2018
Published: 10 August 2018
Abstract

Non-invasive prenatal screening (NIPS) using cell-free DNA is being offered to an increasing number of pregnant women. In this observational study, the authors found chromosome 21, 18, and 13 aneuploidies in a mixed risk factors pregnancy population using NIPS, and found 23 cases with NIPS high risk. They also found that the NIPS results of two cases with hysteromyoma were positive. There were 61 cases in all with maternal gynaecological tumor and the positive rate was 3.28%, which suggests that there may be a specific relationship between them and more evidence is urgently required. Among 23 cases, most had normal results with early or middle pregnancy serologic examination or ultrasonic testing. Therefore, NIPS is more accuracy and could mostly make up for regular prenatal in diagnosis. In addition, NIPS could avoid the risks such as intrauterine infection and miscarriage caused by amniocentesis karyotyping analysis, therefore, the clinical promoter of NIPS during pregnancy is very meaningful.
Keywords
Fetal aneuploidies
Non-invasive prenatal screening (NIPS)
Mixed risk factors
Pregnant women
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