Introduction: Uterine rupture in the second trimester before the onset of labor is a rare condition that can lead to high maternal morbidity and fatal fetal outcome. Case Report: The authors report a case of spontaneous uterine rupture in a 35-year-old woman at the 16^th week of a twin gestation, after IVF. She presented with intraperitoneal haemorrhage, maternal collapse, fetal demise, and required immediate surgical management. Conclusions: Uterine rupture in a primigravid uterus is a rare but life-threatening situation. Studies have shown that the unscarred uterus is not immune to such an event. Even though it is not a common complication, it should always be considered in primigravid women presenting with abdominal pain, hemodynamic instability, and indications of fetal demise.