Objective: To evaluate the efficacy of three methods in the treatment of adenomyosis (ADM). Materials and Methods: Retrospective analysis of the clinical data of 180 patients with ADM diagnosed in the First Affiliated Hospital of Xinjiang Medical University from2010 January to 2013 January, including 75 cases of hysterectomy (Group A), 30 cases underwent ultrasound guided radiofrequency ablation (group B), and 75 cases of gonadotropin releasing hormone (GnRH) conservative drug treatment (Group C). Results: Hysterectomy is an effective treatment, but the patients will lose reproductive function, and may lead to premature ovarian failure. GnRH drugs are not exact, long course of treatment, the price is expensive, and the side effect is important. radiofrequency ablation has little side effect, hospitalization time is short, less treatment cost, will not change the ovarian blood supply, does not affect ovarian function, for patients with fertility requirements, and uterine aspiration and retention can be used as the preferred method of treatment. Conclusion: Ultrasound guided radiofrequency ablation treatment of uterine adenomyosis, as a minimally invasive technique to preserve the uterus, and radiofrequency ablation is expected to be new targeting ways for ADM, to make up the deficiency of existing treatment methods, maintain the retention period uterine endocrine function and endometrial shedding, maintain the patients physiological and psychological balance, and prevent reproductive tract infection, and is expected to become the safe, effective new way of treatment of ADM.