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Original Research
Increased kisspeptin mRNA expression derived from abnormally adhered placenta: compensatory inhibition of abnormal placental invasion?
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1
Ministry of Justice, Transparency and Human Rights, Department of Forensic Medicine of Patras, Rio, Greece
2
Department of Obstetrics and Gynecology, University of Patras Medical School, Rio, Greece
3
Division of Reproductive Endocrinology, University of Patras Medical School, Rio, Greece
Clin. Exp. Obstet. Gynecol. 2018, 45(2), 204–208;
https://doi.org/10.12891/ceog3913.2018
Published: 10 April 2018
Abstract
Purpose of investigation: In normal conditions, circulating kisspeptin levels dramatically increase during the first trimester of pregnancy and fall approximately five days post-delivery to concentrations comparable to those detected prior to pregnancy. Dysregulation of trophoblast invasion results in a wide spectrum of abnormal pregnancies such as preeclampsia, premature delivery, and choriocarcinoma. The aim of the present study was to investigate the expression profile of KiSS-1 in abnormally adherent placenta specimens (placenta accreta and placenta praevia). Materials and Methods: Ten term trophoblast preparations (five normal adhesions, four placenta accretae and one placenta praevia) were obtained for RNA extraction and immunohistochemistry in order to determine KiSS-1 mRNA and protein levels. Results: KiSS-1 mRNA expression was found to be increased in conditions of pathological placental adhesion compared to normal tissues. Conclusion: KiSS-1 is implicated in the regulation of placental invasion as part of a compensatory inhibition to abnormal placental adhesion.
Keywords
Kisspeptin
Placenta
Placenta accreta