IMR Press / CEOG / Volume 45 / Issue 2 / DOI: 10.12891/ceog3853.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
Delayed administration method of clomiphene citrate during the ovulatory phase in patients with a prolonged menstrual cycle
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1 Department of Obstetrics and Gynecology, Kohseichuo General Hospital, Tokyo, Japan
Clin. Exp. Obstet. Gynecol. 2018, 45(2), 299–302;
Published: 10 April 2018

For patients with a prolonged menstrual cycle who do not respond to clomiphene citrate, the drug can be administered again at a higher dose during another cycle. Clomiphene citrate should be administrated two to five days after the start of menstruation; however, enhanced ovulation effects may occur as a potential adverse reaction to high-dose clomiphene citrate therapy, which limits its use. Furthermore, the ovulatory-phase timing of administration differs between normal patients and those with a prolonged menstrual cycle. This indicates clomiphene citrate does not directly act on the ovulatory phase. The authors used a delayed administration of clomiphene citrate without increasing its doses in a patient with a prolonged menstrual cycle who did not respond to conventional clomiphene citrate therapy. They achieved three pregnancies and deliveries in the patient using this method.
Intracyclic clomiphene citrate therapy
Menstrual cycle
Delayed administration
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