Objective: To study the relationship between qh+ and recurrent spontaneous abortion (RSA). Design: Experimental study using human samples. Setting: University-affiliated hospital. Materials and Methods: Eight hundred sixty couples (1,720 cases) with RSA were taken as the RSA group and 871 sterile couples (1,742 cases) with a normal gestation history who came for consultation regarding oviduct factors were taken as the normal group. Intervention(s): The chromosome was collected from peripheral blood of patients. By analyzing the karyotypes of 860 couples (1,720 cases) with RSA and 871 sterile couples (1,742 cases) with a normal gestation history who underwent a consultation purely for oviduct factors. Results: One hundred ninety-three cases of chromosome polymorphisms were diagnosed in the RSA group, with a detection rate of 11.22%, among which 81 cases of qh+ were detected, with a detection rate of 4.71% (81/1720). These cases accounted for 41.97% of the cases of chromosome polymorphisms. The detection rate of chromosome polymorphisms in the normal group was 2.41% (42/1742). Comparison of the two indicates the statistical significance (p < 0.01) of these disparities in the detection rates of both chromosome polymorphisms and qh+. Conclusions: Chromosome polymorphism qh+ is related to RSA, which could provide theoretical foundations for genetic counseling and sound child rearing.