IMR Press / CEOG / Volume 45 / Issue 1 / DOI: 10.12891/ceog3836.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Levels of EG-VEGF and VEGF in serum and in the follicular fluid on the day of oocyte retrieval and reproductive outcome among IVF patients
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1 Center for Reproductive Health, Institute of Mother and Child, Warsaw, Poland
2 Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
3 Department of Obstetrics, Women's Diseases and Oncogynecology, Central Clinical Hospital of Ministry of Interior and Administration, Warsaw, Poland
4 Novum, Fertility Clinic, Warsaw, Poland
Clin. Exp. Obstet. Gynecol. 2018, 45(1), 93–97; https://doi.org/10.12891/ceog3836.2018
Published: 10 February 2018
Abstract

The aim of this retrospective, observational, case control study was to investigate the correlation of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and vascular endothelial growth factor (VEGF) concentrations in serum and follicular fluid (FF) in women undergoing controlled ovarian hyperstimulation (COH) protocols and IVF/ICSI with the reproductive outcome. When the authors compared levels of EG-VEGF and VEGF in FF and serum, they did not observe differences in the group without pregnancy compared to the group of patients with clinical pregnancy (EG-VEGF, respectively, p = 0.12, p = 0.94, and p = 0.16 and VEGF p = 0.16, p = 0.6, and p = 0.32). The authors found lower levels of EG-VEGF in FF from large follicles in the group of patients with clinical pregnancy who miscarried compared to the group of patients who had no pregnancy (p = 0.04); when they compared this group with the group of patients who delivered a baby, there was no statistical significance. Lower levels of EG-VEGF in the follicular fluid from large follicles are negatively correlated with positive outcome of IVF, and correlate with miscarriage rates in patients after IVF.
Keywords
Vascular endothelial growth factor
Endocrine gland-derived vascular endothelial growth factor
Controlled ovarian hyperstimulation
IVF/ICSI
Pregnancy
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