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Original Research
Pregnancy outcomes after fresh-D3 versus frozen-D5 embryo transfer in women with an ectopic pregnancy history: a retrospective cohort study
Lei Yan1, Bing-Qian Zhang1, Xin-Xin Xu1, Zhen Xu1, Ting Han1, Xiu-Ling Fan1, Zi-Jiang Chen1, 2, 3, 4, 5*
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1
Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan
2
National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China
3
The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China
4
Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Clin. Exp. Obstet. Gynecol. 2018, 45(1), 58–62;
https://doi.org/10.12891/ceog3742.2018
Published: 10 February 2018
Abstract
Background: Few studies have investigated the differences between fresh D3 embryo transfer (Fre-D3) and cryopreserved-thawed D5 embryo transfer (Fro-D5) cycles in women with an ectopic pregnancy (EP) history. The aim of this study is to evaluate different pregnancy outcomes between fre-D3 and Fro-D5 embryo transfer cycles in women with an EP history. Materials and Methods: The authors performed a retrospective cohort study in a university-based reproductive medicine center including 2,777 Fre-D3 cycles and 1,120 fro- D5 cycles from 2009 to 2014. Ectopic pregnancy and delivery rates were measured. Results: The incidence of EP after IVF/ICSI in the Fro-D5 was lower than in Fre-D3 cycles (0.48% vs. 2.81%).There were significant differences in the clinical pregnancy rate (61.17% vs. 53.61%), delivery rate (50.00% vs. 43.62%), implantation rate (48.20% vs. 32.03%), and multiple pregnancy rate (26.25% vs.36.68%) between Fro-D5 and Fre-D3. The Fro-D5 group had a significantly lower EP rate (0.45% vs. 2.84) and higher delivery (52.23% vs. 43.28%) and implantation rates (55.98% vs. 35.42%) than the Fre- D3 group. Conclusion(s): The results suggest that women who have an EP history have a lower recurrence risk of EP and a better pregnancy outcome, including delivery rate during Fro-D5 cycles than Fre-D3 cycles.
Keywords
Ectopic pregnancy
Blastocyst transfer
In vitro fertilization
Pregnancy outcome