IMR Press / CEOG / Volume 44 / Issue 6 / DOI: 10.12891/ceog3592.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Ovarian response predictive model in different controlled ovarian stimulation protocols for IVF/ICSI treatment
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1 Clinic for Obstetrics and Gynecology, Clinical Center of Serbia, Belgrade, Serbia
2 Medical Faculty, University of Belgrade, Belgrade, Serbia
3 Department for Medical Statistics and Informatics, Medical Faculty, University of Belgrade, Belgrade, Serbia
Clin. Exp. Obstet. Gynecol. 2017, 44(6), 923–928; https://doi.org/10.12891/ceog3592.2017
Published: 10 December 2017
Abstract

Purpose of investigation: Assesment of biomarkers of the ovarian reserve for ovarian response prediction using different controlled ovarian stimulation (COS) treatments. Materials and Methods: A retrospective cohort study included 363 patients who underwent assisted reproduction at the Clinic of Gynecology and Obstetrics, Belgrade, Serbia. Antral follicle count (AFC), serum AMH, inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone were measured on the second cycle day prior to stimulation commencement. Three types of ovulation stimulation protocols were used. The number and quality of obtained oocytes were used for evaluation of the ovarian response. Results: Patients’ age, number of antral follicles, AMH level, and FSH/LH ratio were confirmed as predictors of the number of obtained oocytes. The AFC was the main parameter that influenced the number of obtained oocytes regardless of selected stimulation protocol. Conclusion: The individualization of stimulation protocols may be further improved by using both AFC- and AMH-tailored approach.
Keywords
Controlled ovarian stimulation (COS)
Ovarian reserve
anti-Mullerian hormone (AMH)
Antral follicle count (AFC)
Ovarian response
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